The Ketogenic Diet

The Ketogenic Diet


• high-fat,

• adequate protein,

• lowcarbohydrate diet

• used for the treatment of intractable childhood epilepsy since the 1920s.


• Jesus
• Huge conklin-1921,water diet
• Geyelin-1921,AMA convention
• Phenytoin-1938
• Charlie foundation-1992

Mechanisms of action

• Ketone bodies-GABA

• Increased expression ofGlial fibrillary acidic protein(GFAP) in dentate gyrus of hippocampus

• Depressive effect on synoptic reorganisation

• Calorie restriction alone has been demonstrated in mice to impair seizure susceptibility. this may activate ATP sensitive potassium channels that may critically be involved in the regulation of seizure activity.


• several epilepsy syndromes,

• particularly in myoclonic astatic epilepsy, Dravets syndrome, and tuberous sclerosis

• focal and generalised epilepsy

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