The Ketogenic Diet
• adequate protein,
• lowcarbohydrate diet
• used for the treatment of intractable childhood epilepsy since the 1920s.
• Huge conklin-1921,water diet
• Geyelin-1921,AMA convention
• Charlie foundation-1992
Mechanisms of action
• Ketone bodies-GABA
• Increased expression ofGlial fibrillary acidic protein(GFAP) in dentate gyrus of hippocampus
• Depressive effect on synoptic reorganisation
• Calorie restriction alone has been demonstrated in mice to impair seizure susceptibility. this may activate ATP sensitive potassium channels that may critically be involved in the regulation of seizure activity.
• several epilepsy syndromes,
• particularly in myoclonic astatic epilepsy, Dravets syndrome, and tuberous sclerosis
• focal and generalised epilepsy