Amino Acids and Peptides

Biomolecules: Amino Acids and Peptides
Lecture 4 Outline
●Present and discuss the properties of amino acids
●Discuss the importance of pKa values and amino acid titration curves
●NOTE: Ignore the techniques section in your book chapter 4 (p. 33-34)
Non-protein Amino Acids
Examples of Clinical Aminoacidurias
●Metabolic defects: Phenylketonuria (Phe), Tyrosinemias (Phe,Tyr), Maple Syrup Urine Disease (Leu, Val, Ile), Alcaptonuria (Tyr)
●Absorption/transport defects: cystinuria (Cys), Hartnup disease , Fanconi’s Syndrome
●These diseases are generally diagnosed from indicators in the urine or plasma. These diseases will be discussed further in the amino acid metabolism lectures
Post-translational Modifications
Levels of Protein Structure

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